Sana Khan began her career in modeling and went on to appear in advertisements and TV shows. She first appeared in the reality show MTV Scooty Teen Diva in 2009.Although, she was eliminated after 5 weeks, it landed her a short role in the teen musical series Ishaan: Sapno Ko Awaaz De. She was next part of the second season of the TV serial Kitani Mohabbat Hai, after which she played the role of Lavanya Kashyap in the Star Plus serial Iss Pyaar Ko Kya Naam Doon? and Riya Mukherjee an important role in the 4 Lions Films criminal investigation series Arjun. Later Sana had to quit the show as she had health problems.She subsequently participated in Femina Miss India and won the title Femina Miss Beautiful Smile 2012.
In 2014, she made her feature film debut in the Telugu film Dikkulu Choodaku Ramayya,changing her screen name to Sana Makbul. In the film she played the role of Samhitha, an aerobics trainer,with whom a father and son fall in love.She has signed and started filming for her first Tamil film, Rangoon, a romantic drama directed by Rajkumar Periasamy.