Neha Dhupia made her film debut in the 2003 Bollywood film Qayamat: City Under Threat (2003), which had an average performance at the box office. She rose to fame with her role Julie and then appeared in Sheesha (2005) in a dual role of twin sisters but it did not do well at the box office. She then starred in films such as Kyaa Kool Hai Hum (2005) and Shootout at Lokhandwala (2007), which did well at the box office, and featured in a segment of the anthology film Dus Kahaniyaan (2007).
In the following years, Dhupia appeared in supporting roles in multiple critically and commercially acclaimed films including Chup Chup Ke (2006), Ek Chalis Ki Last Local (2007), Mithya (2008), Maharathi (2008), Singh Is Kinng (2008) and Dasvidaniya (2008). In 2011, she played Eva Braun in the film Dear Friend Hitler about Mahatma Gandhi.
Her most recent films are Paying Guest, Action Replayy, De Dana Dan and Pappu Can't Dance Saala. She has worked on her first international project with Chris Kattan in IFC's Bollywood Hero. Neha Dhupia may work on a Julie sequel in a few years.
Neha Dhupia has currently no spouse. Although she had dated with Ritwik Bhattacharya and Jimmy Sylvester the relationships were broken by certain reasons that were not hers and she,according to The Hindustan Times 6 dec 2014,states her view about marriage as why marry to share a bathroom and wardrobe and so she still remains single.